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Sickle cell disease (SCD) is characterised by the polymerisation of haemoglobin S (HbS) under low oxygen conditions, causing red blood cells to become rigid and…

Children with sickle cell anemia (SCA), the most common and severe form of sickle cell disease (SCD), show signs of altered development in specific regions of the…

These findings shed light on disruptions in normal blood cell development (hematopoiesis) that may be shared by sickle cell disease and clonal hematopoiesis.…

AbstractPatients with sickle cell disease (SCD) experience multisystem complications, with sickle cell nephropathy being a major contributor to chronic kidney…

The RUBY trial demonstrates that disrupting the BCL11A binding site in the γ-globin promoters can normalize hemoglobin in severe sickle cell disease.Background: The…

The BEACON clinical trial showed therapy's lasting benefits in 31 patientsBeam Therapeutics plans to ask the U.S. Food and Drug Administration (FDA) to approve…

The Focus on Sickle Cell (FoSCel) Foundation has announced that the Great Hall of the Kwame Nkrumah University of Science and Technology (KNUST) in Kumasi will host…

A major step forward for sickle cell care in Georgia is now awaiting the governor's signature.On the final day of the 2026 legislative session, lawmakers passed…

Anaemia is a common condition characterised by a lower-than-normal number of red blood cells or haemoglobin in the blood. Anaemia is a major health concern in India…

Background: Sickle cell disease is a hereditary hemoglobinopathy commonly seen in sub-Saharan Africa, India, and the Middle East. It is caused by a mutation in the…