Hand Foot Syndrome in Sickle Cell Anemia

Hand Foot Syndrome in Sickle Cell Anemia: II. Epidemiology Often the first vaso-Occlusion crisis finding in young children Occurs in up to 50% of children with Sickle Cell Anemia by the age of 2 years Rare over age 4 years old III. Pathophysiology A. Not to be confused with Hand Foot Syndrome that occurs with certain Chemotherapy agents in non-sickle disease B. Occurs in Sickle Cell Anemia with vaso-Occlusion C. Caused by infarction of Bone Marrow 1. Metacarpal or Metatarsal Bones and phalanges IV. Symptoms Painful swelling and tenderness of either the hand or foot Digits may appear mildly erythematous Abstract source