Sickle cell spectrum includes sickle cell trait (SCT) and sickle cell disease (SCD) and manifestations range from relatively benign to life threatening. SCT is common affecting almost 3,000,000 Americans and SCD affects approximately 100,000. There are important considerations for sports, exercise, and conditioning in individuals on the sickle cell spectrum. This chapter explores the epidemiology and pathogenesis of SCT and SCD and reviews the effects of exercise and sport in these conditions. In addition, basketball-specific issues are examined.
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