Transfusion Practices and Strategies for Individuals With Hemoglobin Disorders

Introduction • Describe the optimal hemoglobin level when transfusing a sickle cell patient • List common reasons for transfusing individuals with sickle cell disease • Recognize common complications of transfusion in sickle cell disease • Locate current evidence-based recommendations for transfusion in sickle cell disease Case 1: Use of Transfusion during Acute Illness • Recognize indications for red blood cell transfusion during acute illness in individuals with sickle cell disease • Describe appropriate selection of blood products for transfusion during acute illness in individuals with SCD • Identify management strategies for acute splenic sequestration in SCD • Describe indications for RBC transfusion prior to elective surgical procedures in SCD Case 2: Delayed Hemolytic Transfusion Reactions • Describe practice recommendations for transfusion in sickle cell disease patients with acute chest syndrome • Explain the pathophysiology of delayed hemolytic transfusion reactions and hyper hemolysis • List techniques for evaluating alloantibodies and DHTR • Explain the assessment and management of DHTR Case 3: Management of Chronic Transfusion • Describe the role of chronic transfusion in preventing and managing certain complications of sickle cell disease • Describe prevention and management of alloimmunization in individuals on chronic transfusion • Describe the importance of iron overload in chronically transfused patients with sickle cell disease • Describe the management of iron overload in patients on chronic transfusion Abstract source