Clinical Trial
Study Details
The purpose of this study is to demonstrate that a sufficient number of iron-overloaded thalassemia (THAL), Sickle Cell Disease (SCD)and Diamond Blackfan Anemia (DBA) populations with similar duration of chronic transfusion, and age at start of transfusions would be available for a confirmatory study. The study will examine the hypothesis that a chronic inflammatory state in SCD leads to hepcidin- and cytokine-mediated iron withholding within the RES (reticuloendothelial system), lower plasma NTBI (non-transferrin bound iron) levels, less distribution of iron to the heart in SCD.
Study Overview
A detailed iron burden, transfusion and chelation history will be obtained from chart review or from participant recall.
Iron burden data will include: 1) documentation of liver iron, and 2) average annual ferritin values.
Transfusion data will include: (1) age at onset of regular transfusions, (2) years of chronic transfusion therapy, and (3) pre-transfusion Hb calculated as average of all assessments for each year.
Contacts and Locations
Children's Hospital & Research Center Oakland
Oakland, California 94609
United States
Georgia Regents University
Augusta, Georgia 30912
United States
Children's Memorial Hospital
Chicago, Illinois 60614
United States
Adult Comprehensive Sickle Cell Center, Duke University Medical Center
Durham, North Carolina 27710
United States
Thomas Jefferson SCD Program
Philadelphia, Pennsylvania 19107
United States
St. Jude Children's Research Hospital
Memphis, Tennessee 38105-3678
United States
Universitätsklinikum Hamburg-Eppendorf
Hamburg-Eppendorf
Germany
UCL Cancer Institute
London
WC1E 6BT
United Kingdom