Clinical Trial
Study Details
defibrotide will be given prophylactically prior to AlloSCT to determine if it decreases the incidence of SOS in this high risk population, and determine that it is safe and feasible to give along with myeloimmunoablative therapy and allogeneic transplant.
This is a follow-up trial to NYMC 526 (NCT01461837) to assess the safety, efficacy and toxicity of administering Defibrotide prophylaxis for high-risk sickle cell or beta thalassemia patients undergoing a familial haploidentical or MUD allogeneic stem cell transplantation with CD34 enrichment and T-cell addback. This patient population historically has a risk of developing sinusoidal obstructive syndrome (SOS) and Defibrotide has demonstrated efficacy in treatment of SOS. The Funding Source is FDA OOPD.
Study Overview
Contacts and Locations
University of California Los Angeles
Los Angeles, California 90095
United States
University of Florida
Gainesville, Florida 32610-0278
United States
New York Medical College
Valhalla, New York 10595
United States
Medical College of Wisconsin
Milwaukee, Wisconsin 53226
United States