Clinical Trial
Study Details
Parents and child's doctor may plan to use or not to use hydroxyurea.
The BABY HUG Treatment Study was designed to see if treatment with the drug hydroxyurea (also called HU) in children with sickle cell disease could prevent organ damage, especially in the spleen and kidneys. There was also a chance that treatment could prevent painful crises, lung disease, stroke, and blood infection.
Study Overview
The current observational trial, Follow-Up Study ((FUS) II includes enhanced neuropsychological, brain, cardiac, and pulmonary evaluations for this very well characterized cohort of subjects. Measures of spleen and renal function and markers of DNA damage will continue to be collected. Assessment of other target organs in sickle cell disease including pulmonary and cardiac function will be performed in addition to evaluation of developmental aspects of sickle cell disease (SCD) and potential HU toxicity.
Contacts and Locations
University of Alabama at Birmingham
Birmingham, Alabama 35233
United States
Children's National Medical Center Center for Cancer and Blood Disorders
Washington D.C., District of Columbia 20010
United States
Howard University College of Medicine
Washington D.C., District of Columbia 20060
United States
University of Miami School of Medicine
Miami, Florida 33136
United States
Emory University School of Medicine
Atlanta, Georgia 30342
United States
Johns Hopkins University School of Medicine
Baltimore, Maryland 21205
United States
Sinai Hospital of Baltimore Alfred I Coplan Pediatric Hematology Oncology Outpatient Center
Baltimore, Maryland 21215
United States
Children's Hospital of Michigan/Wayne State University
Detroit, Michigan 48201
United States
University of Mississippi Medical Center
Jackson, Mississippi 39216
United States
Downstate Medical Center
Brooklyn, New York 11203
United States
Duke University Medical Center
Durham, North Carolina 27710
United States
Medical University of South Carolina
Charleston, South Carolina 29425
United States
St. Jude Children's Research Hospital
Memphis, Tennessee 38105
United States
University of Texas Southwestern Medical Center at Dallas
Dallas, Texas 75390
United States