Phase I/II Randomized Study of Hydroxyurea With or Without Clotrimazole in Patients With Sickle Cell Anemia

Clinical Trial
Study Details
Enrollment
20
Interventions
Name
clotrimazole
Type
Drug
Name
hydroxyurea
Type
Drug
Phase
Phase 1
Phase 2
Status
COMPLETED
Study ID #
NCT00004492
Study Type
Interventional
Summary

OBJECTIVES:

I. Compare the efficacy of hydroxyurea with or without clotrimazole in terms of limiting the severity of anemia and the rate of hemolysis in patients with sickle cell anemia.

Study Overview
Conditions
Sickle Cell Anemia
Description

PROTOCOL OUTLINE: This is a randomized study. Patients are randomized to one of two treatment arms.

Arm I: Patients receive oral hydroxyurea and oral clotrimazole daily for 12 months.

Arm II: Patients receive oral hydroxyurea daily for 12 months. Patients are followed at 6 weeks.

Completion date provided represents the completion date of the grant per OOPD records

Contacts and Locations
Locations
Facility

University of North Carolina School of Medicine
Chapel Hill, North Carolina 27599-7070
United States

GeoPoint
35.9132, -79.05584